Temporal analysis of the infiltration dynamics of pro-inflammatory cytokine-producing innate and adaptive immune cells following experimental traumatic brain injury in mice
Sahil Threja, Nathan Strogulski, Janeen Laabei, Béré Diallo, Carly Douglas, Kingston Mills, David Loane · FENS Forum 2024
Traumatic brain injury (TBI) is the leading cause of death and disability in young adults. A key factor in the aftermath of TBI is the response to pro-inflammatory cytokines such as interleukin(IL)-1β (IL-1β), tumor necrosis factor (TNF-α), IL-6, IL-17, and interferon-γ (IFNγ). This preclinical study examined key cytokine-producing cells post-TBI in mice.Adult C57BL/6J male mice underwent controlled cortical impact or sham surgery. Mice were euthanized, and brains harvested acutely at 3 hours (h), 6h, 12h, 24h post-injury, or subacutely at 3, 10, and 28 days post-injury (DPI). Mononuclear cell
ePoster · Neuroscience