Interleukin 1 signaling modulates pro- and anti-neurogenic effects through activation of interleukin 1 receptor type 1 on different cell types
Maria Smirnova, Marianne Monet, Daniel Nemeth, Henriette van Praag, Ning Quan · FENS Forum 2024
Adult hippocampal neurogenesis (AHN) occurs the dentate gyrus (DG) and is a dynamic process which functions in learning and memory. Increased AHN improves cognition and is therapeutic for neurodegeneration. However, loss of AHN is implicated in neurodegenerative disorders, thus understanding the mechanisms that modulate AHN could lead to targeted therapeutics. The master regulator of neuroinflammation, Interleukin-1 (IL-1), is a proinflammatory cytokine that signals via interleukin 1 receptor type 1 (IL-1R1) and decreases AHN. However, blockade of IL-1 signaling suppresses AHN indicating IL-1
ePoster · Neuroscience