Topic: interleukin 6

Traumatic brain injury (TBI) is a major cause of mortality and morbidity, including long-lasting cognitive impairment – linked to disrupted brain connectivity. Phospholipids (PL) are key components of cellular membranes, also essential for synaptic structural integrity. It has been shown that the multi-nutrient combination Souvenaid® which contains PL precursors, improves neurological outcomes in experimental TBI. We hypothesised that this intervention could support brain recovery, and we tested the feasibility of providing this multi-nutrient to TBI patients.In a randomised, placebo-controlle

Interleukin 6 (IL-6), its receptor (IL-6R), with the IL-6 signal transducer gp130 (IL-6ST) are well known regulators of innate immunity but also affect neuron morphology and function. More recent evidence suggests that they also play a significant role in shaping microbiota composition and gut-barrier function (1). However, the exact pathways and mechanisms are still elusive. We therefore investigated the involvement of functional IL-6 signaling in the bilateral communication between primary afferent neurons and gut microbiota.Transgenic mice with a conditional depletion of gp130 in neurons ex