The modulation of p75 neurotrophin receptor reduces oxidative stress and inflammation in a cellular model of Rett syndrome
Michela Varone, Mayra Colardo, Noemi Martella, Daniele Pensabene, Marco Segatto · FENS Forum 2024
Rett syndrome (RTT) is an early-onset neurological disorder that primarily affects females, causing severe cognitive and physical disabilities. Recently, an imbalance in redox homeostasis and exacerbated inflammatory response have been shown to play a central role in the diverse clinical manifestations of the disease.Numerous studies have highlighted that p75 neurotrophin receptor (p75NTR) may have a role in the regulation of oxidative stress (OS) and inflammation.Therefore, the aim of this work was to evaluate whether the modulation of p75NTR by LM11A-31 counteracts the alterations in OS and
ePoster · Neuroscience