Locomotor learning under climbing fiber control
Alice Geminiani, Ana Gonçalves, Hugo Gravato Marques, Francesco Costantino, Tatiana Silva, Merit Kruse, Megan R. Carey · FENS Forum 2024
The cerebellum plays a key role in motor learning, adapting movements in response to perturbations or errors. For simple tasks like eyeblink classical conditioning, climbing fibers originating in the inferior olive and projecting to the cerebellum provide neural instructive signals sufficient to drive learning. For complex whole-body behaviors like locomotion, however, it is not known what role climbing fibers play. We recently demonstrated (Darmohray et al., 2019) that mice running on a split-belt treadmill (that controls the speed under each side of the body independently) exhibit a form of
ePoster · Neuroscience