Functional internally tagged Vps10p-domain receptors: A novel tool to investigate their endosomal itineraries, dimerization, and ligand interactions that reveals their potential role in BDNF transport
Marcel Klein, Antonio Virgilio Failla, Guido Hermey · FENS Forum 2024
The Vps10p-Domain (Vps10p-D) receptor family consists of Sortilin, SorLA, SorCS1, SorCS2 and SorCS3. They mediate internalization and intracellular sorting of specific cargo in various cell types, including neurons, but underlying molecular determinants are incompletely understood. Deciphering the dynamic intracellular itineraries of Vps10p-D receptors is crucial for understanding their role in physiological and cytopathological processes. However, studying their spatial and temporal dynamics by live imaging has been challenging so far, as terminal tagging with fluorophores presumably impedes
ePoster · Neuroscience