Rectifying interneuron developmental trajectory prevents the core symptoms of autism spectrum disorder in mice
Shaam Al Abed, Nathan Reynolds, William Kwan, Rhea Laverock, Archana Sritharan, Yovina Sontani, Alexandre Rcom-H'cheo-Forgues, Mirindra Ratsifandrihamanana, Michel Picardo, Nathalie Dehorter · FENS Forum 2024
The emergence of the core traits in autism spectrum disorder (ASD), which includes altered social interactions, communication, and repetitive movements, stems from impaired excitation-inhibition (E/I) balance of key brain structures (i.e. the prefrontal cortex, hippocampus, and striatum). Whilst interneuron hypofunction has been attributed to ASD presentation, no research has attempted to restore their activity from early stages of brain development to alleviate core traits. Here, searching for molecular regulators of interneuron function, we examined the involvement of the Neurokinin 3 recept
ePoster · Neuroscience