A connectome manipulation framework for the systematic and reproducible study of structure-function relationships through simulations
Christoph Pokorny, Omar Awile, James B. Isbister, Matthias Wolf, Michael W. Reimann · FENS Forum 2024
Even with complete knowledge of the underlying wiring diagram based on electron microscopy and of neuronal activity through in vivo recordings, we can only ever correlate neuron function with the structure of connectivity. Causation, however, can only be proven by manipulations of connectivity, which can experimentally only be pursued on coarse-grained scales or with low specificity. Higher resolution and specificity can, to date, only be reached using simulation techniques. Here, we present a novel framework for rapid connectome manipulations of detailed, biologically realistic network models
ePoster · Neuroscience