Distinct structural dynamics of CA1 inhibitory synapses in neuronal compartments during memory formation
Hannah Klimmt, Alessandro Ulivi, David Kappel, Bhargavi Keerthana Boovaraga Murthy, Alessio Attardo · FENS Forum 2024
The formation of new memories requires the hippocampus, a brain region which exhibits high levels of structural plasticity. Within the dorsal hippocampal CA1, specific interneuron subtypes synapse onto specific subcellular compartments of Pyramidal Neurons (PNs) such as dendrites, soma and axon initial segment (AIS) thus shaping the cellular computations underlying memory formation. Yet, very little is known about the long-term structural dynamics of these compartmentalized inhibitory synapses on PNs and their link to learning.To address these outstanding questions, we used longitudinal in viv
ePoster · Neuroscience