Acute stress, microbial metabolites and the microbiota-gut-brain axis: Focus on microbial regulation of barrier function and hippocampal plasticity
Cristina Rosell-Cardona, Sarah-Jane Leigh, Emily G Knox, Michael K Collins, Nancy Kelley-Loughnane, Michael S Goodson, John F Cryan, Gerard Clarke · FENS Forum 2024
Acute stress exposures are the building blocks of chronic stress. Unravelling the mechanisms underpinning the whole-body response to acute stress is critical to understand this neglected aspect of health and disease. A single acute stress exposure rapidly modulates gut-brain axis signalling including intestinal permeability and hippocampal plasticity. The gut microbiota is increasingly recognized as an important modulator of mood and cognition, and microbially-produced metabolites such as butyrate can be a key regulator of brain and gut function via the gut-brain axis. The aim of this work is
ePoster · Neuroscience