Three-dimensional organization of connexin clusters along axonal cisternal organelle networks in human pyramidal neurons
Jan Maximilian Janssen, Giulia Glatting, Tobias Herbinger, Florence Pelletier, Christophe Leterrier, Maren Engelhardt · FENS Forum 2024
High-frequency oscillations (HFOs) have been observed to be particularly prominent in brain regions responsible for seizure initiation and propagation. Connexins play a crucial role in fast intercellular communication within the brain, as they are integral components of gap junctions, which facilitate direct cytoplasmic connections between neighboring cells. Recent studies identified clusters of connexins within the rodent CNS, specifically along the axon initial segment (AIS), a critical neuronal microdomain responsible for the initiation of action potentials. However, details about the subce
ePoster · Neuroscience