The Janus faces of nanoparticles at the neurovascular unit: A double-edged sword in neurodegeneration
Giulia Terribile, Sara Di Girolamo, Paolo Spaiardi, Gerardo Biella, Silvia Sesana, Francesca Re, Giulio Alfredo Sancini · FENS Forum 2024
Recently, several disorders of the central nervous system (CNS), including Alzheimer's disease (AD) and neuroinflammation have been associated with dysfunction of the neurovascular unit (NVU). As a result, there is an increased demand for therapeutic tools able to act at the NVU. We studied liposomes functionalized with apolipoprotein-E and phosphatidic acid (mApoE-PA-LIP), previously used to promote Aβ removal across the blood-brain barrier (BBB) in an in vivo model of AD, with memory improvement. We performed calcium imaging to study ATP-evoked intracellular Ca2+ waves in hCMEC/D3 and in ast
ePoster · Neuroscience