Topic: intrahippocampal kainic acid mouse model

Aims: Temporal lobe epilepsy is a neurological disorder characterised by the occurrence of spontaneous seizures. Current treatment methods consist of anti-epileptic drugs, resective surgery or neuromodulation each with significant risks and/or side-effects. Responsive neuromodulation could provide a solution by providing spatial and temporal specificity. In this study, we evaluated whether seizures could be detected with a self-designed embedded system and terminated through activation of the WiChR opsin in the intrahippocampal kainic acid mouse model of temporal lobe epilepsy.Methods: Mice we