Time window for early intervention in tauopathy mouse model
Benito Maffei, Nathaneal O'Neill, Guru Padmasola, Marco Leite, Chiara Dyson, Francisco Moreira, Vincent Magloire, Dimitri Kullmann, Gabriele Lignani · FENS Forum 2024
Early changes in network activity serve as distinctive hallmarks in tauopathies such as Alzheimer’s Disease and Frontotemporal Dementia. Decades before the onset of cognitive decline, many patients experience seizures which exacerbate the condition. Despite the recognised etiological overlaps between tauopathies and epilepsies, the relationship between tau and the development of circuit hyperexcitability is unclear and needs further investigation. Using wireless EEG to record intrahippocampal local field potentials (LFP), we characterised early biophysical alterations within the hippocampus of
ePoster · Neuroscience