A novel rat pup model that recapitulates the clinical phenotype of intraventricular hemorrhage-induced hydrocephalus in human preterm neonates
Kwang Min Kim, Mohamed Rafiuddin Ahmed, Megan Phillips, Andrey Malkovskiy, Venkata Raveendra Pothineni, Jayakumar Rajadas, Chirag B Patel, Kelly B Mahaney · FENS Forum 2024
Hydrocephalus is a disorder that involves accumulation of cerebrospinal fluid (CSF) in the ventricles of the brain. The incidence is significantly higher in preterm neonates, which is highly associated with intraventricular hemorrhage (IVH). The sequela of severe IVH manifests post-hemorrhagic hydrocephalus (PHH) that contributes to neurologic morbidity and mortality in preterm infants. There have been numerous animal models to study the mechanism and progression of hydrocephalus since 1913. However, we still lack an IVH-induced hydrocephalus model that accurately reflects the gestational age
ePoster · Neuroscience