Modeling the effects of schizophrenia-related ion-channel encoding genes on P50 suppression
Jan Fredrik Kismul, Torbjørn Ness, Christoph Metzner, Torbjørn Elvsåshagen, Gaute Einevoll, Ole Andreassen, Marja-Leena Linne, Tuomo Mäki-Marttunen · FENS Forum 2024
P50 suppression is a sensory gating phenomenon where the EEG response to the second out of two auditory clicks is decreased in amplitude. Clinical studies have reported the magnitude of P50 suppression to be impaired in schizophrenia. Here, we used a network model of multicompartmental neurons to explore the mechanisms of P50 suppression deficits in schizophrenia. The model consisted of a population of pyramidal neurons interconnected with two interneuron populations: large basket cells and neurogliaform cells, where the latter activates GABAB-receptor mediated post-synaptic currents in its ta
ePoster · Neuroscience