Behavioral and histological hallmarks of an intrastriatal rotenone mouse model for Parkinson’s disease
Paula Jauregi Barandica, Roland Rabl, Magdalena Daurer, Livia Breznik, Stefanie Flunkert, Boris Philippe Chagnaud, Manuela Prokesch · FENS Forum 2024
Parkinson’s disease (PD) is a neurodegenerative disease characterized by the loss of dopaminergic neurons in the substantia nigra (SN) pars compacta, leading to motor and cognitive impairments. The lack of a cure for this disease highlights the urgency in finding drugs that can modify its course. This emphasizes the importance of creating preclinical models that mimic major aspects of the disease. Rotenone, a natural pesticide that inhibits the mitochondrial complex I, has been shown to induce inflammation and selectively destroys nigrostriatal dopaminergic cells and thus presents itself as a
ePoster · Neuroscience