DNA damage during early neurogenesis impairs interneuron migration without altering their ultimate cortical positioning
Lisa Berden, André-Claude Mbouombouo Mfossa, Lotte Vingerhoets, Isabeau De Bie, Najat Aourz, Mieke Verslegers, Ilse Smolders, Jean-Michel Rigo, Bert Brône, Nicholas Rajan, Roel Quintens · FENS Forum 2024
Proper interneuron migration and distribution are essential for optimal brain function. Disruptions of this process can impair the excitation/inhibition balance, leading to neurodevelopmental disorders. As such, ionizing radiation poses a particular risk to the developing brain, as it can lead to excessive fetal DNA damage and subsequent microcephaly. Although research on radiation-induced microcephaly has mainly focused on glutamatergic excitatory neurons, the impact on GABAergic interneurons is equally crucial. Understanding potential disruptions is essential for comprehensive insights into
ePoster · Neuroscience