Spine synapses newly formed during motor learning accompany more distant perisynaptic astrocytic processes compared to stable synapses in mouse primary motor cortex
Mohammed Youssef, Jaerin Sohn, Estilla Toth, Christopher K Salmon, Yasuo Kawaguchi, Yoshiyuki Kubota · FENS Forum 2024
Perisynaptic astrocytic processes (PAPs) in excitatory tripartite synapses play an important role for the synaptic transmission through glutamate clearance, ions homeostasis, and synapse isolation. Here, we analyzed the proximity of PAPs to the synaptic interface at spines on the tuft dendritic branches of layer 5 pyramidal cells in the mouse primary motor cortex (M1) during a skillful motor seed reaching task (Sohn et al., 2022. Science Advances, eabm0531). Mice were trained daily for this task and in vivo imaging was conducted on days 0, 4, and 8. The animals were perfused after day 8 and ti
ePoster · Neuroscience