IL-1-PIP3 signal cascade mediates epilepsy and sleep disturbances
Shu-Hui Huang, Pei-Lu Yi, Fang-Chia Chang · FENS Forum 2024
Aims: Interleukin-1β (IL-1β) in the central nervous system initiates a PI3K signaling cascade, involving crucial membrane phospholipids phosphatidylinositol (4,5)-bisphosphate (PIP2) and phosphatidylinositol (3,4,5)-trisphosphate (PIP3). While PIP2's role in epileptogenesis is known, our study investigates the unclear role of PIP3 using PTZ-induced epileptic mice, exploring its impact on epileptogenesis and associated sleep disruptions. Methods: Our hypothesis proposed a pivotal role for PIP3 in the molecular mechanism of seizures. We intraperitoneal administered low dose of PTZ once every two
ePoster · Neuroscience