Characterization of the autophagic-lysosomal pathway in Parkinson’s disease using patient iPSC-derived dopaminergic neurons containing a LRRK2 G2019S mutation
Sandra Coveney, Virginia Bain, Kayley LeFrancois, Maia Zoller, Supriya Singh, Coby Carlson, A Fathi, Scott Schachtele, Richard Cho · FENS Forum 2024
Dopaminergic neuron cell death in Parkinson’s Disease (PD) is complex and combinatorial, with impairments in multiple cellular pathways impacting mitochondrial function, endosomal/lysosomal protein degradation, alpha-synuclein and tau aggregation, and neuroinflammation. Genetic risk factors, such as mutations in leucine-rich repeat kinase 2 (LRRK2) and glucocerebrosidase (GBA), have been shown to impact kinetics of the autophagiclysosomal pathway (ALP), which is suggested to contribute to PD-associated protein accumulation and aggregation. Human-relevant in vitro models using patient-derived i
ePoster · Neuroscience