Topic: IQ motif

Nuclear receptor interaction protein (NRIP) composes of 860 amino acids, includes 7 WD40 domains and 1 IQ motif. NRIP is a member of acetylcholine receptor (AChR) complex which plays an important role in the formation of neuromuscular junction (NMJ). Autoimmune deficiency is often associated with neuropathy. Myasthenia gravis (MG) is an autoimmune disease of NMJ. Previously, we characterized that NRIP autoantibody is found in myasthenia gravis and correlated with disease progression when anti-AChR autoantibody occurred. Amyotrophic lateral sclerosis (ALS) is a fetal neurodegenerative disease a