Topic: iron-binding

Introduction: Neonatal hypoxia-ischemia (HI) is a leading cause of mortality and chronic disability. Hypothermia (HT) is the gold standard for the treatment of term babies; however, its neuroprotective effects are limited. Lactoferrin (LF) is the major whey protein in milk presenting iron-binding, anti-inflammatory and anti-apoptotic against HI damage. We hypothesize that combining oral administration of LF to the dams enhances the neuroprotection caused by HT following experimental HI. Methods: Pregnant Wistar rats were fed with bovine LF-supplemented diet (1mg/kg) or Control diet from P6 to