Detrimental effects of high-density STAT3-mediated astrocytic corralling in glioblastoma multiforme
Paula Martínez Remedios, Elena Saavedra, Paola Casanova, Meritxell Roig-Martínez, Mario Vázquez, Irina Freitag, Maider Usandizaga, María Ángeles Carrillo-de Sauvage, Carole Escartin, Carlos Barcia · FENS Forum 2024
Glioblastoma multiforme is the most common and aggressive malignant brain tumor in adults. One of the factors contributing to the progression is the complex tumor microenvironment. Specially, the coexistence of two cell types, tumoral cells and resident astrocytes, sharing genetic and phenotypical backgrounds. This aspect hinders the phenotypical and functional distinction of both cell types during tumor development. Here, we found a differential expression of the astrocytic markers GFAP and S100β that allowed us to histologically distinguish between tumoral cells and resident astrocytes in GB
ePoster · Neuroscience