Topic: juvenile male mice

The Autism Spectrum Disorder (ASD) is a pervasive neurodevelopmental condition, more prevalent in males, characterized by social behavior impairments. Exposure to valproic acid (VPA) during pregnancy is linked to ASD. In our VPA-mouse model experiment, we examined neuronal activation in the social decision-making network (SDMN) and stress-regulatory nuclei in the brain of juvenile male mice across diverse social settings. VPA treatment effectiveness was validated through a three-chamber sociability test, a standard method for measuring ASD-like behavior. WE used c-Fos immunohistochemistry to c