Vasopressin shifts the excitation-inhibition balance in the olfactory bulb network via differential effects on olfactory bulb neuron subtypes
Hajime Suyama, Gaia Bianchini, Max Müller, Luna Jammal, Veronica Egger, Michael Lukas · FENS Forum 2024
Vasopressin (VP) cells in the rat olfactory bulb (OB) have unique features compared to other types of external tufted cells, with olfactory nerve input inhibiting them and added cholinergic neuromodulation enabling them to fire. However, how VP modulates bulbar synaptic transmission to facilitate social discrimination is still unclear. As first step, we recorded responses to olfactory nerve stimulation and their modulation by VP (1 µM) using electrophysiology as well as 2-photon population Ca2+ imaging in acute OB slices. We first investigated the excitatory middle tufted and mitral cells. In
ePoster · Neuroscience