Topic: Karyoptosis

During neurodegeneration, dying neuronal cells may influence or inform neighboring glial cells of their dying status by releasing extracellular vesicles (EVs). During a recently characterized cell death, Karyoptosis, EVs are released, and it is yet to be understood what role they play in neurodegeneration. This project sits at the nexus of understanding neuronal cell death in neurodegeneration and exploring EVs as messengers in neuron-microglia signaling. Using ex vivo brain sections from DRPLA mice we validated the anatomical correlation between areas with high Karyoptosis and microglia activ