Topic: KCC2 membrane clustering

Neuronal chloride homeostasis is determined by KCC2 and NKCC1 transporters responsible for chloride efflux and influx. KCC2 internalization and increased NKCC1 surface expression leads to a pathological state by accumulation of chloride in neurons. Molecules designed to reduce intra-neuronal chloride levels - by stabilizing KCC2 or destabilizing NKCC1 at the membrane - represent promising therapeutic strategies for diseases in which inhibition is impaired. The WNK/SPAK kinase pathway, by regulating the phosphorylation and membrane stability of both NKCC1 and KCC2, constitutes a new target of i