Mutations in potassium channel beta subunits perturb sleep state transitions in mice
Haram Park, Zelie Britton, Paul Volkmann, Yeonsoo Choi, Emma Charlett-Green, Gero Miesenböck · FENS Forum 2024
Recent advances in understanding the biomolecular mechanisms of sleep control in the Drosophila model have implicated mitochondrial ROS as a key cog in the machine. Hyperkinetic, the beta subunit to the potassium channel Shaker, has been shown to act as a conduit translating rising levels of that mitochondrial ROS during waking hours to heightened cell excitability in the sleep-controlling dorsal fan-shaped body-projecting neurons (dFB) in flies. In order to explore the universality of this mechanism, we instigated a parallel study in mice. Hyperkinetic has three homologs in the mammalian geno
ePoster · Neuroscience