Topic: KCNQ1

KCNQ1 is the pore-forming alpha subunit of a voltage-dependent potassium channel complex. It is predominantly expressed in the heart and in the inner ear, however, it is also present in the brain. Genetic variants in KCNQ1 have been linked to several disorders, like Romano-Ward syndrome, Jervell and Lange Nielson syndrome and diabetes mellitus type 2. Moreover, KCNQ1 is also discussed to contribute to the pathogenesis of Alzheimer´s disease and neurodevelopmental disorders, even though it´s function in the human brain remains unknown. In this study we aim to elucidate the function of KCNQ1 in