ID-linked lysine demethylase 1A and 5C functionally collaborate to prevent gene derepression and neuronal malfunction in adult excitatory neurons
Juan Paraiso, Ana Maria Martin, Beatriz del Blanco, Sergio Niñerola, Angel Barco · FENS Forum 2024
Lysine demethylases (KDMs) play a pivotal role in the establishment of cell fate and their loss or reduction has been linked to neurodevelopmental disorders and intellectual disability (ID). Kdm1a and Kdm5c are two of the most expressed KDMs in hippocampal neurons. The two enzymes converge in maintaining a repressive state, consequently, the ablation of either one of them in adult hippocampal excitatory neurons triggered the derepression of non-neuronal genes in neurons. To explore the functional interaction between the two proteins we generated and characterized double inducible and forebrain
ePoster · Neuroscience