Cross species single-cell/nucleus RNA-seq uncovers the evolutionarily conserved pathological mechanisms of vascular contribution to Alzheimer’s disease
Elanur Yilmaz, Prabesh Bhattarai, Ozkan Is, Xue Wang, Yuhao Min, Nastasia Nelson, Annie J. Lee, Mehmet I. Cosacak, Badri Vardarajan, Richard Mayeux, Nilufer Ertekin-Taner, Caghan Kizil · FENS Forum 2024
The latest scientific advancements have revealed previously unidentified genes correlated with the concurrent presence of vascular pathologies and Alzheimer's disease (AD). Yet, the biological functions and mechanisms underlying their contribution to the disease pathology remain to be elucidated. Animal models enabling efficient functional screenings are essential. In pursuit of this aim, we created transgenic adult zebrafish models to investigate the pathological effects of amyloid toxicity. We conducted transcriptome analyses in zebrafish models, integrated with and compared to single nucleu
ePoster · Neuroscience