Non-dividing “immature” neurons in subcortical brain regions of mammals display phylogenetic variation with clear prevalence in primates
Marco Ghibaudi, Nikita Telitsyn, Jean-Marie Graïc, Irmgard Amrein, Chet C. Sherwood, Luca Bonfanti · FENS Forum 2024
Brain structural plasticity is heterogeneous in mammals, due to adaptation to ecological pressures. Whether the genesis of new neurons (stem cell-driven adult neurogenesis) is reduced from mice to humans, we recently demonstrated that a population of prenatally generated (non-dividing) “immature” neurons (INs) retaining the expression of immaturity markers (e.g., doublecortin; DCX), is highly abundant in the cerebral cortex of gyrencephalic species. Presence of DCX-positive (DCX+) cells has been reported also in subcortical regions of some mammals, yet the results regarding their origin are co
ePoster · Neuroscience