A human isogenic pluripotent stem cell system for determining the role of sex chromosomes on microglia function in Alzheimer’s disease
Noemi Gatto, Emma Davis, Ruta Meleckyte, Verity Mitchener, Millie Thackray, Mark Fiers, Bart De Strooper, James Turner, Lorena Arancibia-Cárcamo · FENS Forum 2024
Alzheimer's disease (AD) exhibits sex-specific prevalence rates, yet the molecular mechanisms underlying these differences remain elusive. Neuroinflammation, specifically the microglia response, is thought to have a prominent role in AD pathogenesis. This study seeks to understand how sex chromosomes influence human microglia response to amyloid accumulation and how this may contribute to sexual dimorphisms in AD pathology. Inducible pluripotent stem cells (iPSCs) were generated from a donor with Klinefelter’s syndrome (XXY) and modified to express one or 2 sex chromosomes (XX, XY, XO). Microg
ePoster · Neuroscience