Spontaneous and tonic action potential firing is sustained by membrane potential instabilities in peripheral sensory neurons
Enrique Velasco, Michael Mazar, Alina Milici, Ellaline Cami, María José Giner, Víctor Meseguer, Juana Gallar, Alexander Binshtok, Julio Álvarez, Karel Talavera · FENS Forum 2024
Sustained action potential firing (SAPF) is a feature shared by multiple neuronal types and is crucial for stimulus encoding, neural communication and circuit plasticity. We aimed at unveiling the mechanisms underlying SAPF in Peripheral Sensory Neurons (PSNs), a convenient experimental model for studying single-cell excitability. Current-clamp recordings in primary-cultured PSNs revealed that tonic depolarization elicits Subthreshold Membrane Potential Transients (SMPTs) in 82% of this cells, and statistical analyses indicates that larger and faster SMPTs are causally associated with SAPF. Ph
ePoster · Neuroscience