Unraveling the interplay: Behavioral and electrophysiological insights into the protective impact of curcumin and L-thyroxine on hippocampal activity in amyloid beta peptide (25-35)-injected rats
Lilit Darbinyan, Lilia Hambardzumyan, Larisa Manukyan, Lilit Avetisyan, Karen Simonyan · FENS Forum 2024
Aims: Alzheimer's disease (AD), a neurodegenerative disorder, exhibits cognitive decline via plaque formation, inflammation, cholinergic deficits, and oxidative stress. Curcumin, derived from turmeric, exhibits neuroprotective properties, potentially counteracting AD and Parkinson's disease. With anti-inflammatory, anti-oxidant, insulin-sensitizing properties, it inhibits protein aggregation. Despite the crucial role of thyroid hormones in memory, there is limited electrophysiological evidence supporting these effects.Methods: This study, involving adult Wistar rats, aimed to explore the impac
ePoster · Neuroscience