Lactate influences the m6A RNA methylation of genes involved in neuronal function
Fathia Ben-Rached, Anel Lopez-Gonzalez, Gabriel Herrera-Lopez, John S. Girgis, Pierre J. Magistretti, Hubert Fiumelli · FENS Forum 2024
The Astrocyte-Neuron Lactate Shuttle model posits that lactate is transferred from astrocytes to neurons to fulfill energetic needs and act as a signal that regulates gene expression related to neuroprotection, neuronal excitability, synaptic plasticity, and memory. N6-methyladenosine (m6A), the most abundant internal modification of RNA, influences mRNA stability, translation, transport, localization, and alternative splicing. This dynamic epitranscriptomic mark is prevalent in the nervous system, impacting various processes, including those affected by lactate, such as neurogenesis, synaptic
ePoster · Neuroscience