Bridging in vivo and in vitro recordings in the human epileptic neocortex: Patient-wise comparative analysis of single-unit activities
Réka Bod, Berta Börcsök, Kinga Tóth, Estilla Zsófia Tóth, Loránd Erőss, Dániel Fabó, István Ulbert, Lucia Wittner · FENS Forum 2024
Epilepsy provides a unique opportunity to study human cellular electrophysiology through in vivo and in vitro approaches. In vivo recordings offer advantages in action potential pattern reconstruction and connection preservation, while in vitro studies allow broader tissue exploration within a confined space of cut connections, yet coherent investigation in these distinct conditions is lacking. This study compared single-neuron firing properties in four epileptic patients using identical 24-channel laminar microelectrodes with 150 μm inter-contact distance for both their in vivo and in vitro i
ePoster · Neuroscience