Topic: late endosome/lysosome

Charcot-Marie-Tooth type 2B (CMT2B) is a peripheral sensory neuropathy caused by mutations in the late endosome/lysosome associated small GTPase Rab7A. While progress has been made in characterizing the biochemical and functional consequences of CMT2B-causing mutations, the mechanisms leading to the degeneration of neurons with very long axons are still unclear. We recently found that Rab7-positive acidic compartments are involved in axonal protein synthesis, a process that is essential for neuronal function and maintenance. These intriguing findings prompted us to better understand lysosomal