Differences in the frequency-dependency of LTP and LTD at lateral and medial perforant path synapses in rodent dentate gyrus reflect distinct roles in information encoding
Jens Colitti-Klausnitzer, Hardy Hagena, Valentyna Dubovyk, Denise Manahan-Vaughan · FENS Forum 2024
The medial (MPP) and lateral perforant path (LPP) inputs to the dentate gyrus (DG) comprise a prominent source of information for the hippocampus. Behavioral and anatomical studies have indicated that the MPP provides information about metric space and the LPP provides information about item identity to the hippocampus. This may influence how information is encoded in MPP and LPP inputs to the hippocampus.Here, we examined the frequency-dependency of synaptic plasticity in MPP-DG and LPP-DG synapses of the dorsal hippocampus of freely behaving adult male rats using patterned afferent stimulati
ePoster · Neuroscience