Contribution of MEC layer II cells to DG granule cells’ spatial activity revealed by transgenic chemogenetic manipulation
Thibault Cholvin, Mohammad R Govahi, Clifford G Kentros, Marlene Bartos · FENS Forum 2024
The dentate gyrus (DG) plays a key role in the emergence of spatial and contextual map representation within the hippocampus during learning. Granule cells (GCs) of the DG receive their major spatial cortical input from the medial entorhinal cortex (MEC) via the perforant path. To determine whether inputs from the MEC (in particular layer II stellate cells) play a role in the capacity of the DG to differentiate between different environments, we aim to modulate their activity using DREADDs. Thanks to these pharmacogenetic tools, we can de- or hyper-polarize MEC-layer II stellate cells during e
ePoster · Neuroscience