Topic: LC optogenetic modulation

Sensory stimuli, including auditory, visual, or tactile inputs, can elicit varied brain and bodily responses contingent upon their novelty and salience levels. Human functional magnetic resonance imaging (fMRI) studies have delineated brain regions involved in salience detection, suggesting a feedforward propagation of brain activity from sensory to associative areas. Longstanding theories have emphasized the significance of the Locus Coeruleus – Norepinephrine (LC/NE) system in governing the levels of salience in sensory signals. However, causal evidence linking LC activity to alterations in