Rab5-associated transcriptome reveals a new link between endosomes and autophagy in axons
Francesca Pappacena, Cinzia Caterino, Cristina Sironi, Jean-Michel Cioni · FENS Forum 2024
RNA localization is particularly important in morphologically complex cells such as neurons, where precise protein expression is necessary to achieve highly compartmentalized functions. Emerging evidence suggests that endosomal trafficking could be directly involved in RNA localization and translation in neurons. However, the identity of endosomal-regulated mRNAs, and the functional role of endosomes in controlling subcellular protein synthesis, remain to be understood. By coupling proximity labeling and RNA sequencing, we here report the presence of a rich repertoire of mRNAs associated with
ePoster · Neuroscience