Topic: left–right coordination

Long propriospinal neurons coordinate activities between limb-specific neural circuitry in the cervical and lumbar enlargement. Silencing of either ascending or descending long propriospinal neurons in intact rats results in a disruption of left–right coordination. Yet, their silencing after a moderate thoracic contusive injury significantly improves locomotion. The underlying mechanisms are unclear and further complicated by the context-dependency of the phenotypes, and likely involve afferent feedback and biomechanical constraints. Here, we present an integrated neurorobotic model of quadrup