Topic: letters of intent

Exploratory brain and nervous-system research helps new independent investigators generate evidence for larger research programmes. Mandatory letters of intent are due November 3, 2026, at 5 p.m. Eastern; full applications follow February 17, 2027.

Supports Phase 1–3 trials of combination approaches for Alzheimer’s disease and related dementias, with mechanistic rationale and appropriate biomarkers. Phase 1 support is capped at USD 1 million; Phase 2–3 at USD 2 million over two to three years. Exceptional requests up to USD 3 million require case-by-case consideration. Letters of intent are due 20 October 2026 at 17:00 Eastern time (22 October for ISTAART members); invited full applications follow on 15 December (17 December for members).

The Simons Foundation Autism Research Initiative supports bold, high-risk, high-reward ideas that could open new directions in autism science. Letters of intent are accepted on a rolling basis, with selected applicants invited to submit a full application for projects lasting up to two years.