Behavioral performance of mice in open field test (OFT) exposed to the combination of levetiracetam (LEV) and valproic acid (VPA) (1:1) during whole gestation
Jelena Podgorac Kojadinovic · FENS Forum 2024
Introduction: The rational polytherapy of epilepsy during pregnancy is challenging. VPA represents an old antiepileptic with broad spectrum indications and LEV is relatively new antiepileptic used for the treatment of generalized tonic-clonic and juvenile myoclonic epilepsy and adjunctive therapy for focal seizures. Combination of these two antiepileptics during pregnancy, according to the cohort study (Gašparović at al., 2020), was the most common. Aim: The aim of the present study was to assesse the behavioral performance of the mice whose mothers were treated with combination of VPA and LEV
ePoster · Neuroscience