Multimodal Ising-based connectomics reveals an excitation-inhibition imbalance in Alzheimer's Risk
Drew Burns, Igor Fortel, Liang Zhan, Orly Lazarov, Scott Mackin, Alexander Demos, Barbara Bendlin, Alex Leow · COSYNE 2025
The balance between neural excitation and inhibition (E/I) is crucial for cognitive functions such as memory formation and retrieval. Disruptions in E/I balance are implicated in neurodegenerative diseases like Alzheimer's disease (AD), where neuronal hyperexcitation has been observed. We present a novel multimodal model that integrates resting-state functional MRI and diffusion-weighted imaging to recapitulate functional and structural connectivity dynamics with high fidelity (citations omitted: double-blind review). This model provides a whole-brain, systems-informed measure of excitation-in
ePoster · Neuroscience