Regional cortical excitability critically biases interareal fMRI connectivity
David Sastre, Federico Rocchi, Simone Blanco Malerba, Alexia Stuefer, Jean Charles Mariani, Filomena Gracia Alvino, Shahryar Noei, Ludovico Coletta, Alberto Galbusera, Stefano Panzeri, Alessandro Gozzi · FENS Forum 2024
Resting-state fMRI (rsfMRI) is widely used to map brain network organization in healthy and pathological states. However, the neural underpinnings governing brainwide fMRI functional connectivity (interareal activity correlation) remain unclear. Neocortical excitatory/inhibitory (E/I) balance critically affects local and long-range information processing and can conceivably bias fMRI connectivity, as suggested by the widely reported neocortical E/I imbalance and altered fMRI connectivity in multiple brain disorders. Here, we combine chemogenetics, rsfMRI and electrophysiology to causally probe
ePoster · Neuroscience