Erythropoietin restrains the inhibitory potential of interneurons in the mouse hippocampus
Yasmina Curto, Héctor Carceller, Patrycja Klimczak, Marta Perez-Rando, Vicent Teruel-Marti, Manvendra Singh, Hannelore Ehrenreich, Juan Nácher · FENS Forum 2024
Cognitive impairment and disturbed excitatory-inhibitory balance in the brain have been linked to severe psychiatric illnesses such as schizophrenia, affective disorders, and autism spectrum disorders. Erythropoietin (EPO) may have a role in mitigating them by rectifying hippocampal transcriptional networks and synaptic architectures of pyramidal lineages when administered to juvenile mice. How EPO involves interneurons to rebuild synapses is an impending puzzle. After examining ~12,000 single-nuclei transcriptomic data, we generated a comprehensive molecular atlas of hippocampal interneurons,
ePoster · Neuroscience