Topic: light ON-OFF responses

The retina processes and transmits visual signals throughout a defined neuronal circuit to retinal ganglion cells, which project to the visual centers of the brain. Microglia have been shown to fine-tune the neuronal circuitry by pruning functionally weak synapses during brain development. However, we do not know whether microglia have a similar impact on the neuronal circuit of the retina.In mice, microglia invade the developing retina as early as embryonic age (E) 11.5, where they reside in in the emerging outer- (OPL) and inner plexiform layer (IPL) throughout adulthood. Here, we investigat